Journal article

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: Evidence from Bayesian mapping

Kit Melissa Larsen, Morten Morup, Michelle Rosgaard Birknow, Elvira Fischer, Line Olsen, Michael Didriksen, William Frans Christiaan Baare, Thomas Mears Werge, Marta Isabel Garrido, Hartwig Roman Siebner



One of the most common copy number variants, the 22q11.2 microdeletion, confers an increased risk for schizophrenia. Since schizophrenia has been associated with an aberrant neural response to repeated stimuli through both reduced adaptation and prediction, we here hypothesized that this may also be the case in nonpsychotic individuals with a 22q11.2 deletion. We recorded high-density EEG from 19 individuals with 22q11.2 deletion syndrome (12-25 years), as well as 27 healthy volunteers with comparable age and sex distribution, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Using posterior probability maps and dynamic causal modelling we tested three differ..

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Awarded by Lundbeck Foundation, Denmark

Awarded by Lundbeck Foundation

Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant)

Awarded by University of Queensland Fellowship

Funding Acknowledgements

This study was funded by the Lundbeck Foundation, Denmark (R155-2014-1724); Lundbeck Foundation [Grant of Excellence "ContAct" R59 A5399]; Lundbeck Foundation fellowship (R105-9813); The Capital Region's Research Foundation for Mental Health Research; the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant 140100007CE); University of Queensland Fellowship (2016000071) to MIG. H.R.S. holds a professorship in precision medicine at the Faculty of Health Sciences and Medicine, University of Copenhagen, sponsored by the Lundbeckfonden.