Journal article

White matter connectivity reductions in the pre-clinical continuum of psychosis: A connectome study

Lena KL Oestreich, Roshini Randeniya, Marta Garrido

Human Brain Mapping | WILEY | Published : 2019

Abstract

Widespread white matter connectivity disruptions have commonly been reported in schizophrenia. However, it is questionable whether structural connectivity decline is specifically associated with schizophrenia or whether it extends along a continuum of psychosis into the healthy population. Elucidating brain structure changes associated with psychotic-like experiences in healthy individuals is insofar important as it is a necessary first step towards our understanding of brain pathology preceding florid psychosis. High resolution, multishell diffusion-weighted magnetic resonance images (MRI) were acquired from 89 healthy individuals. Whole-brain white matter fibre tracking was performed to qu..

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Grants

Awarded by Foundation Research Excellence Award


Awarded by University of Queensland Fellowship


Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function


Funding Acknowledgements

Foundation Research Excellence Award, Grant/Award Number: 2016001844; University of Queensland Fellowship, Grant/Award Number: 2016000071; Australian Research Council Centre of Excellence for Integrative Brain Function, Grant/Award Number: CE140100007