Journal article

Alteration of functional brain architecture in 22q11.2 deletion syndrome - Insights into susceptibility for psychosis

Kit Melissa Larsen, Ilvana Dzafic, Hartwig Roman Siebner, Marta Isabel Garrido

NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2019

Abstract

The 22q11.2 deletion is one of the most common copy number variants in humans. Carriers of the deletion have a markedly increased risk for neurodevelopmental brain disorders, including schizophrenia, autism spectrum disorders, and attention deficit hyperactivity disorder. The high risk of psychiatric disorders associated with 22q11.2 deletion syndrome offers a unique possibility to identify the functional abnormalities that precede the emergence of psychosis. Carriers of a 22q11.2 deletion show a broad range of sensory processing and cognitive abnormalities similar as in schizophrenia, such as auditory and visual sensory processing, response inhibition, working memory, social cognition, rewa..

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Grants

Awarded by Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant)


Awarded by University of Queensland Fellowship


Funding Acknowledgements

MIG acknowledges funding from the Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant CE140100007) and a University of Queensland Fellowship (2016000071). HRS holds a professorship in precision medicine at University of Copenhagen which is sponsored by Lundbeckfonden.