Journal article

Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome

Kit Melissa Larsen, Morten Morup, Michelle Rosgaard Birknow, Elvira Fischer, Oliver Hulme, Anders Vangkilde, Henriette Schmock, William Frans Christiaan Baare, Michael Didriksen, Line Olsen, Thomas Werge, Hartwig R Siebner, Marta I Garrido

Schizophrenia Research | ELSEVIER SCIENCE BV | Published : 2018

Abstract

22q11.2 deletion syndrome (22q11.2DS) is one of the most common copy number variants and confers a markedly increased risk for schizophrenia. As such, 22q11.2DS is a homogeneous genetic liability model which enables studies to delineate functional abnormalities that may precede disease onset. Mismatch negativity (MMN), a brain marker of change detection, is reduced in people with schizophrenia compared to healthy controls. Using dynamic causal modelling (DCM), previous studies showed that top-down effective connectivity linking the frontal and temporal cortex is reduced in schizophrenia relative to healthy controls in MMN tasks. In the search for early risk-markers for schizophrenia we inves..

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