Journal article

The Unpredictive Brain Under Threat: A Neurocomputational Account of Anxious Hypervigilance

Brian R Cornwell, Marta I Garrido, Cassie Overstreet, Daniel S Pine, Christian Grillon

Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2017

Abstract

BACKGROUND: Anxious hypervigilance is marked by sensitized sensory-perceptual processes and attentional biases to potential danger cues in the environment. How this is realized at the neurocomputational level is unknown but could clarify the brain mechanisms disrupted in psychiatric conditions such as posttraumatic stress disorder. Predictive coding, instantiated by dynamic causal models, provides a promising framework to ground these state-related changes in the dynamic interactions of reciprocally connected brain areas. METHODS: Anxiety states were elicited in healthy participants (n = 19) by exposure to the threat of unpredictable, aversive shocks while undergoing magnetoencephalography. ..

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Grants

Awarded by Intramural Research Program of the National Institute of Mental Health Grant


Awarded by University of Queensland


Funding Acknowledgements

This work was supported in part by the Intramural Research Program of the National Institute of Mental Health Grant No. ZIAMH002798 (Protocol 02-M-0321; NCT00047853 to CG), a NARSAD Young Investigator Award from the Brain & Behavior Research Foundation (to BRC), and a University of Queensland Fellowship Grant No. 2016000071 (to MIG).