The maturation of mismatch negativity networks in normal adolescence

Abstract

Objective: We investigated the neurophysiological mechanisms underpinning the generation of the mismatch negativity (MMN) and its development from adolescence to early adulthood. Methods: We used dynamic causal modelling (DCM) to study connectivity models for healthy adults and adolescents. MMN was elicited with an auditory oddball paradigm in two groups of healthy subjects with mean age 14 (n = 52) and 26 (n = 26). We tested models with different hierarchical complexities including up to five cortical nodes. Results: We showed that the network generating MMN consisted of 5 nodes that could modulate all intra- and internodal connections. The inversion of this model showed that adolescents ha..