The maturation of mismatch negativity networks in normal adolescence
GK Cooray, MI Garrido, T Brismar, L Hyllienmark
Clinical Neurophysiology | ELSEVIER IRELAND LTD | Published : 2016
OBJECTIVE: We investigated the neurophysiological mechanisms underpinning the generation of the mismatch negativity (MMN) and its development from adolescence to early adulthood. METHODS: We used dynamic causal modelling (DCM) to study connectivity models for healthy adults and adolescents. MMN was elicited with an auditory oddball paradigm in two groups of healthy subjects with mean age 14 (n=52) and 26 (n=26). We tested models with different hierarchical complexities including up to five cortical nodes. RESULTS: We showed that the network generating MMN consisted of 5 nodes that could modulate all intra- and internodal connections. The inversion of this model showed that adolescents had re..View full abstract
This work was supported by Stockholm City Council, Sweden, the Wellcome Trust, London, UK and an Australian Research Council Discovery Early Career Researcher Award to M.I.G. G.K.C was supported by a scholarship from the Swedish Brain Foundation (Hjarnfonden).