Conference Proceedings

11Beta-hydroxysteroid dehydrogenase type 1--a role in inflammation?

Karen E Chapman, James S Gilmour, Agnes E Coutinho, John S Savill, Jonathan R Seckl

Mol Cell Endocrinol | Published : 2006


Glucocorticoids are widely used for their potent anti-inflammatory effects. Endogenous glucocorticoids are immunomodulatory and shape both adaptive and innate immune responses. Over the past decade, it has become apparent that an important level of control over endogenous glucocorticoid action is exerted by the 11beta-hydroxysteroid dehydrogenase enzymes. The type 1 enzyme, 11beta-HSD1, reduces inert glucocorticoids into active forms, thereby increasing intracellular ligand availability to receptors. Although 11beta-HSD1 activity has been shown to play an important role in the metabolic actions of glucocorticoids, its role in the immune response has, until recently, remained unclear. Here we..

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