Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells
Ping Zhang, Jyothy Raju, Md Ashik Ullah, Raymond Au, Antiopi Varelias, Kate H Gartlan, Stuart D Olver, Luke D Samson, Elise Sturgeon, Nienke Zomerdijk, Judy Avery, Tessa Gargett, Michael P Brown, Lachlan J Coin, Devika Ganesamoorthy, Cheryl Hutchins, Gary R Pratt, Glen A Kennedy, A James Morton, Cameron I Curley Show all
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2019
Awarded by National Health and Medical Research Council (NHMRC, Australia)
Awarded by NH&MRC Early Career Fellowship
The authors are thankful to the patients and their families for their participation and cooperation. The authors thank Prof. Malcolm K Brenner at the Center for Cell and Gene Therapy (Baylor College of Medicine, Houston, TX) for the manufacture of clinical grade retrovirus vector. The authors thank Bellicum Pharmaceuticals for providing AP1903 (Rimiducid). This study was supported by a Project Grant (APP1053135) from the National Health and Medical Research Council (NH&MRC, Australia), QIMR Berghofer Ride To Conquer Cancer Flagship Award and Royal Brisbane, and Women's Hospital Foundation. S.-K. Tey was supported by an NH&MRC Early Career Fellowship (APP1054786) and G.R. Hill was supported by a Queensland Health Senior Clinical Research Fellowship.