Journal article

Rapid diagnosis of Capnocytophaga canimorsus septic shock in an immunocompetent individual using real-time Nanopore sequencing: a case report

Seweryn Bialasiewicz, Tania PS Duarte, Son H Nguyen, Vichitra Sukumaran, Alexandra Stewart, Sally Appleton, Miranda E Pitt, Arnold Bainomugisa, Amy V Jennison, Rikki Graham, Lachlan JM Coin, Krispin Hajkowicz

BMC Infectious Diseases | BMC | Published : 2019

Abstract

BACKGROUND: Rapid diagnosis and appropriate treatment is imperative in bacterial sepsis due increasing risk of mortality with every hour without appropriate antibiotic therapy. Atypical infections with fastidious organisms may take more than 4 days to diagnose leading to calls for improved methods for rapidly diagnosing sepsis. Capnocytophaga canimorsus is a slow-growing, fastidious gram-negative bacillus which is a common commensal within the mouths of dogs, but rarely cause infections in humans. C. canimorsus sepsis risk factors include immunosuppression, alcoholism and elderly age. Here we report on the application of emerging nanopore sequencing methods to rapidly diagnose an atypical ca..

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Grants

Awarded by Advance Queensland Innovation Partnerships grant


Funding Acknowledgements

The enhanced diagnostic testing described in this Case Report was supported by the Advance Queensland Innovation Partnerships grant "partnerships16-231". The funding body had no role in the design of the study and collection, analysis, and interpretation of data, or in writing the manuscript.