Journal article

Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions

Hyun Jae Lee, Athina Georgiadou, Thomas D Otto, Michael Levin, Lachlan J Coin, David J Conway, Aubrey J Cunnington

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | AMER SOC MICROBIOLOGY | Published : 2018

Abstract

Transcriptomics, the analysis of genome-wide RNA expression, is a common approach to investigate host and pathogen processes in infectious diseases. Technical and bioinformatic advances have permitted increasingly thorough analyses of the association of RNA expression with fundamental biology, immunity, pathogenesis, diagnosis, and prognosis. Transcriptomic approaches can now be used to realize a previously unattainable goal, the simultaneous study of RNA expression in host and pathogen, in order to better understand their interactions. This exciting prospect is not without challenges, especially as focus moves from interactions in vitro under tightly controlled conditions to tissue- and sys..

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