Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions
Hyun Jae Lee, Athina Georgiadou, Thomas D Otto, Michael Levin, Lachlan J Coin, David J Conway, Aubrey J Cunnington
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | AMER SOC MICROBIOLOGY | Published : 2018
Transcriptomics, the analysis of genome-wide RNA expression, is a common approach to investigate host and pathogen processes in infectious diseases. Technical and bioinformatic advances have permitted increasingly thorough analyses of the association of RNA expression with fundamental biology, immunity, pathogenesis, diagnosis, and prognosis. Transcriptomic approaches can now be used to realize a previously unattainable goal, the simultaneous study of RNA expression in host and pathogen, in order to better understand their interactions. This exciting prospect is not without challenges, especially as focus moves from interactions in vitro under tightly controlled conditions to tissue- and sys..View full abstract
Awarded by European Union
This work was funded by the United Kingdom Medical Research Council (MRC) and the United Kingdom Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 program supported by the European Union (MR/L006529/1 to A.J.C.). We declare no competing financial interests.