Journal article
Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature
VJ Wright, JA Herberg, M Kaforou, C Shimizu, H Eleftherohorinou, H Shailes, AM Barendregt, S Menikou, S Gormley, M Berk, LT Hoang, AH Tremoulet, JT Kanegaye, LJM Coin, MP Glodé, M Hibberd, TW Kuijpers, CJ Hoggart, JC Burns, M Levin
JAMA Pediatrics | AMER MEDICAL ASSOC | Published : 2018
Open access
Abstract
Importance: To date, there is no diagnostic test for Kawasaki disease (KD). Diagnosis is based on clinical features shared with other febrile conditions, frequently resulting in delayed or missed treatment and an increased risk of coronary artery aneurysms. Objective: To identify a whole-blood gene expression signature that distinguishes children with KD in the first week of illness from other febrile conditions. Design, Setting, and Participants: The case-control study comprised a discovery group that included a training and test set and a validation group of children with KD or comparator febrile illness. The setting was pediatric centers in the United Kingdom, Spain, the Netherlands, and ..
View full abstractGrants
Awarded by Hartwell Foundation
Funding Acknowledgements
This work was supported by funding from the National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (grants WMNP_P69099 [Dr Herberg] and DMPED P26077 [Dr Levin]), the Javon Charitable Trust (Dr Levin), the Children of St Mary's Intensive Care Kawasaki Disease Research Fund (Drs Herberg and Levin), an NIHR Senior Investigator Award (Dr Levin), a Gordon and Marilyn Macklin Foundation grant (Dr Burns), The Hartwell Foundation and the Harold Amos Medical Faculty Development Program/Robert Wood Johnson Foundation (Dr Tremoulet), the Stinafo Foundation (Dr Kuijpers), the Academic Medical Centre (University of Amsterdam) 2013 MD/PhD program (Ms Barendregt), and the Wellcome Trust (grant 206508/Z/17/Z) (Dr Kaforou).