Journal article

Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation

Ji Lu, Min Jin, Son Hoang Nguyen, Likai Mao, Jie Li, Lachlan Coin, Zhiguo Yuan, Jianhua Guo

Published : 2018

Abstract

ABSTRACT Antibiotic resistance poses a major threat to public health. Overuse and misuse of antibiotics are generally recognised as the key factors contributing to antibiotic resistance. However, whether non-antibiotic, anti-microbial (NAAM) chemicals can directly induce antibiotic resistance is unclear. We aim to investigate whether the exposure to a NAAM chemical triclosan (TCS) has an impact on inducing antibiotic resistance on Escherichia coli . Here, we report that at a concentration of 0.2 mg/L TCS induces multi-drug resistance in wild-type Escherichia coli after 30-day TCS exposure. The oxidative stress induced by TCS caused genetic mutations in genes such as fabI , frdD , marR , acrR..

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University of Melbourne Researchers