Journal article
Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children
JA Herberg, M Kaforou, VJ Wright, H Shailes, H Eleftherohorinou, CJ Hoggart, M Cebey-López, MJ Carter, VA Janes, S Gormley, C Shimizu, AH Tremoulet, AM Barendregt, A Salas, J Kanegaye, AJ Pollard, SN Faust, S Patel, T Kuijpers, F Martinón-Torres Show all
JAMA Journal of the American Medical Association | AMER MEDICAL ASSOC | Published : 2016
Abstract
IMPORTANCE Because clinical features do not reliably distinguish bacterial from viral infection, many children worldwide receive unnecessary antibiotic treatment, while bacterial infection is missed in others. OBJECTIVE To identify a blood RNA expression signature that distinguishes bacterial from viral infection in febrile children. DESIGN, SETTING, AND PARTICIPANTS Febrile children presenting to participating hospitals in the United Kingdom, Spain, the Netherlands, and the United States between 2009-2013 were prospectively recruited, comprising a discovery group and validation group. Each group was classified after microbiological investigation as having definite bacterial infection, defin..
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Awarded by European Commission
Funding Acknowledgements
This work was supported by the Imperial College Comprehensive Biomedical Research Centre (DMPED P26077); National Institute of Health Research (NIHR) Senior Investigator award (Dr Levin); Great Ormond St Hospital Charity (V1401) (Dr Wright); European Union's Seventh Framework Program (EC-GA 279185) (EUCLIDS) (Dr Herberg); Imperial College-Wellcome Trust Antimicrobial Research Collaborative (ARC) Early Career Fellowship (RSRO 54990) (Dr Kaforou); Spanish Research Program (FIS; PI10/00540 and Intensificacion actividad investigadora of National Plan I + D + I and FEDER funds) and Regional Galician funds (Promotion of Research Project 10 PXIB 918 184 PR) (Dr Martinon-Torres); Southampton NIHR Wellcome Trust Clinical Research Facility and NIHR Wessex Local Clinical Research Network; and Academic Medical Centre Amsterdam MD/PhD program 2013 (Ms Barendregt). The UK meningococcal disease cohort was established with grant support from the Meningitis Research Foundation (United Kingdom); the inflammatory disease cohort was supported by a Macklin Foundation grant (Dr Burns), National Institutes of Health grant U54-HL108460 (Dr Burns); and The Hartwell Foundation and The Harold Amos Medical Faculty Development Program/Robert Wood Johnson Foundation (Dr Tremoulet).