Journal article

Genetic architecture of early childhood growth phenotypes gives insights into their link with later obesity

Maneka De Silva, Sylvain Sebert, Alexessander Couto Alves, Ulla Sovio, Shikta Das, Rob Taal, Nicole Warrington, Alexandra Lewin, Marika Kaakinen, Diana Cousminer, Elisabeth Thiering, Nicholas Timpson, Ville Karhunen, Tom Bond, Xavier Estivill, Virpi Lindi, Jonathan Bradfield, Frank Geller, Lachlan JM Coin, Marie Loh Show all

Published : 2017

Abstract

Abstract Early childhood growth patterns are associated with adult metabolic health, but the underlying mechanisms are unclear. We performed genome-wide meta-analyses and follow-up in up to 22,769 European children for six early growth phenotypes derived from longitudinal data: peak height and weight velocities, age and body mass index (BMI) at adiposity peak (AP ~ 9 months) and rebound (AR ~ 5-6 years). We identified four associated loci ( P < 5x10 −8 ): LEPR/LEPROT with BMI at AP, FTO and TFAP2B with Age at AR and GNPDA2 with BMI at AR. The observed AR-associated SNPs at FTO, TFAP2B and GNPDA2 represent known adult BMI-associated variants. The common BMI at AP associated variant at LEPR/LE..

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University of Melbourne Researchers

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