Journal article

Genetic architecture of early growth phenotypes gives insights into their link with later obesity

M De Silva, S Sebert, A Couto Alves, U Sovio, S Das, RH Taal, N Warrington, AM Lewin, M Kaakinen, D Cousminer, E Thiering, N Timpson, V Karhunen, T Bond, X Estivill, V Lindi, JP Bradfield, F Geller, LJM Coin, M Loh Show all

EUROPEAN JOURNAL OF HUMAN GENETICS | NATURE PUBLISHING GROUP | Published : 2018

Abstract

Early childhood growth patterns are associated with adult metabolic health, but the underlying mechanisms are unclear. We performed genome-wide meta-analyses and follow-up in up to 22,769 European children for six early growth phenotypes derived from longitudinal data: peak height and weight velocities, age and body mass index (BMI) at adiposity peak (AP ~ 9 months) and rebound (AR ~ 5-6 years). We identified four associated loci ( P < 5x10 −8 ): LEPR/LEPROT with BMI at AP, FTO and TFAP2B with Age at AR and GNPDA2 with BMI at AR. The observed AR-associated SNPs at FTO, TFAP2B and GNPDA2 represent known adult BMI-associated variants. The common BMI at AP associated variant at LEPR/LEPROT was ..

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University of Melbourne Researchers