Journal article
A new scoring system derived from base excess and platelet count at presentation predicts mortality in paediatric meningococcal sepsis
Alexessander Couto-Alves, Victoria J Wright, Karnan Perumal, Alexander Binder, Enitan D Carrol, Marieke Emonts, Ronald de Groot, Jan Hazelzet, Taco Kuijpers, Simon Nadel, Werner Zenz, Padmanabhan Ramnarayan, Michael Levin, Lachlan Coin, David P Inwald
CRITICAL CARE | BMC | Published : 2013
DOI: 10.1186/cc12609
Abstract
INTRODUCTION: The aim of this study was to derive a novel prognostic score for mortality in paediatric meningococcal sepsis (MS) based on readily available laboratory markers. METHODS: A multicentre retrospective cohort study for the consortium set and a single centre retrospective study for replication set. The consortium set were 1,073 children (age 1 week to 17.9 years) referred over a 15-year period (1996 to 2011), who had an admission diagnosis of MS, referred to paediatric intensive care units (PICUs) in six different European centres. The consortium set was split into a development set and validation set to derive the score. The replication set were 134 children with MS (age 2 weeks t..
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Awarded by National Institute for Health Research
Funding Acknowledgements
Dr. Inwald is grateful for support from HEFCE and the NIHR Biomedical Research Centre funding scheme. Dr. Couto Alves is grateful for funding from the European Commission.