Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

C Sabatti; SK Service; AL Hartikainen; A Pouta; S Ripatti; J Brodsky; CG Jones; NA Zaitlen; T Varilo; M Kaakinen; U Sovio; A Ruokonen; J Laitinen; E Jakkula; L Coin; C Hoggart; A Collins; H Turunen; S Gabriel; P Elliot; MI McCarthy; MJ Daly; MR Järvelin; NB Freimer; L Peltonen

Journal article

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

C Sabatti, SK Service, AL Hartikainen, A Pouta, S Ripatti, J Brodsky, CG Jones, NA Zaitlen, T Varilo, M Kaakinen, U Sovio, A Ruokonen, J Laitinen, E Jakkula, L Coin, C Hoggart, A Collins, H Turunen, S Gabriel, P Elliot Show all

Nature Genetics | NATURE PUBLISHING GROUP | Published : 2009

DOI: 10.1038/ng.271

Abstract

Genome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation of environmental and genetic influences on complex traits. We report GWAS results for nine quantitative metabolic traits (triglycerides, high-density lipoprotein, low-density lipoprotein, glucose, insulin, C-reactive protein, body mass index, and systolic and diastolic blood pressure) in the Northern Finland Birth Cohort 1966 (NFBC1966), drawn from the most genetically isolated Finnish regions. We replicate most previously reported associations for these traits and identify nine new associations, several of which highlight genes with metabolic functions: high-density lipoprotein with NR1H3 (LXRA),..

View full abstract