Journal article
famCNV: copy number variant association for quantitative traits in families
Hariklia Eleftherohorinou, Johanna C Andersson-Assarsson, Robin G Walters, Julia S El-Sayed Moustafa, Lachlan Coin, Peter Jacobson, Lena MS Carlsson, Alexandra IF Blakemore, Philippe Froguel, Andrew J Walley, Mario Falchi
BIOINFORMATICS | OXFORD UNIV PRESS | Published : 2011
Abstract
UNLABELLED: A program package to enable genome-wide association of copy number variants (CNVs) with quantitative phenotypes in families of arbitrary size and complexity. Intensity signals that act as proxies for the number of copies are modeled in a variance component framework and association with traits is assessed through formal likelihood testing. AVAILABILITY AND IMPLEMENTATION: The Java package is made available at www.imperial.ac.uk/medicine/people/m.falchi/. CONTACT: m.falchi@imperial.ac.uk.
Grants
Awarded by Wellcome Trust
Awarded by Swedish Research Council
Funding Acknowledgements
This study was funded by Grant no. 079534/z/06/z from the Wellcome Trust. The SOS Sibpair study is supported by the Swedish Research Council (K2010-55X-11285-13), the Swedish Foundation for Strategic Research to Sahlgrenska Center for Cardiovascular and Metabolic Research, the Swedish Diabetes foundation and the Swedish federal government under the LUA/ALF agreement.