Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Gunter Schumann; Lachlan J Coin; Anbarasu Lourdusamy; Pimphen Charoen; Karen H Berger; David Stacey; Sylvane Desrivieres; Fazil A Aliev; Anokhi A Khan; Najaf Amin; Yurii S Aulchenko; Georgy Bakalkin; Stephan J Bakker; Beverley Balkau; Joline W Beulens; Ainhoa Bilbao; Rudolf A de Boer; Delphine Beury; Michiel L Bots; Elemi J Breetvelt; Stephane Cauchi; Christine Cavalcanti-Proenca; John C Chambers; Toni-Kim Clarke; Norbert Dahmen; Eco J de Geus; Danielle Dick; Francesca Ducci; Alanna Easton; Howard J Edenberg; Tonu Esko; Alberto Fernandez-Medarde; Tatiana Foroud; Nelson B Freimer; Jean-Antoine Girault; Diederick E Grobbee; Simonetta Guarrera; Daniel F Gudbjartsson; Anna-Liisa Hartikainen; Andrew C Heath; Victor Hesselbrock; Albert Hofman; Jouke-Jan Hottenga; Matti K Isohanni; Jaakko Kaprio; Kay-Tee Khaw; Brigitte Kuehnel; Jaana Laitinen; Stephane Lobbens; Jian'an Luan; Massimo Mangino; Matthieu Maroteaux; Giuseppe Matullo; Mark I McCarthy; Christian Mueller; Gerjan Navis; Mattijs E Numans; Alejandro Nunez; Dale R Nyholt; Charlotte N Onland-Moret; Ben A Oostra; Paul F O'Reilly; Miklos Palkovits; Brenda W Penninx; Silvia Polidoro; Anneli Pouta; Inga Prokopenko; Fulvio Ricceri; Eugenio Santos; Johannes H Smit; Nicole Soranzo; Kijoung Song; Ulla Sovio; Michael Stumvoll; Ida Surakk; Thorgeir E Thorgeirsson; Unnur Thorsteinsdottir; Claire Troakes; Thorarinn Tyrfingsson; Anke Toenjes; Cuno S Uiterwaal; Andre G Uitterlinden; Pim van der Harst; Yvonne T van der Schouw; Oliver Staehlin; Nicole Vogelzangs; Peter Vollenweider; Gerard Waeber; Nicholas J Wareham; Dawn M Waterworth; John B Whitfield; Erich H Wichmann; Gonneke Willemsen; Jacqueline C Witteman; Xin Yuan; Guangju Zhai; Jing H Zhao; Weihua Zhang; Nicholas G Martin; Andres Metspalu; Angela Doering; James Scott; Tim D Spector; Ruth J Loos; Dorret I Boomsma; Vincent Mooser; Leena Peltonen; Kari Stefansson; Cornelia M van Duijn; Paolo Vineis; Wolfgang H Sommer; Jaspal S Kooner; Rainer Spanagel; Ulrike A Heberlein; Marjo-Riitta Jarvelin; Paul Elliott

Journal article

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Gunter Schumann, Lachlan J Coin, Anbarasu Lourdusamy, Pimphen Charoen, Karen H Berger, David Stacey, Sylvane Desrivieres, Fazil A Aliev, Anokhi A Khan, Najaf Amin, Yurii S Aulchenko, Georgy Bakalkin, Stephan J Bakker, Beverley Balkau, Joline W Beulens, Ainhoa Bilbao, Rudolf A de Boer, Delphine Beury, Michiel L Bots, Elemi J Breetvelt Show all

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2011

DOI: 10.1073/pnas.1017288108

University of Melbourne Researchers

Lachlan Coin Author Microbiology and Immunology

Grants

Awarded by European Union

Awarded by United Kingdom National Institute for Health Research (NIHR) Biomedical Research Centre Mental Health, the Medical Research Council

Awarded by German Nationales Genomforschungsnetz

Awarded by Instituto de Salud Carlos III (ISCIII)

Awarded by Junta de Castilla y Leon (JCyL)

Awarded by RTICC, ISCIII, Spain

Awarded by Medical Research Council

Funding Acknowledgements

We thank all of the individuals who participated and contributed to these studies. The Alcohol-GWAS (AlcGen) consortium was brought together as a component project of the European Union-funded European Network on Genomic and Genetic Epidemiology (ENGAGE) Program (HEALTH-F4-2007-201413). Functional genetic research was supported by the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behavior in normal brain function and psychopathology) (LSHM-CT-2007-037286) and FP7 project ADAMS (Genomic variations underlying common neuropsychiatric diseases and disease related cognitive traits in different human populations) (242257), as well as the United Kingdom National Institute for Health Research (NIHR) Biomedical Research Centre Mental Health, the Medical Research Council Programme Grant "Developmental pathways into adolescent substance abuse" (93558), the German Nationales Genomforschungsnetz (01GS08152), and the State of California for Medical Research through the University of California, San Francisco. L.J.C. is supported by a Research Council United Kingdom (RCUK) fellowship. P. C. was supported in part by a grant from the Imperial College Healthcare NHS Trust Comprehensive Biomedical Research Centre funded by NIHR. G. B. was supported by grants from the Swedish Council for Working Life and Social Research (FAS) and Swedish Science Research Council. E. S. was supported by grants from Instituto de Salud Carlos III (ISCIII) (FIS PI021570) and Junta de Castilla y Leon (JCyL) (SA044A08 and GR93) as well as institutional support from RTICC (RD06/0020/000), ISCIII, Spain. P. E. is an NIHR senior investigator. Acknowledgements for participating cohorts are in SI Text.