Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals

TO Kilpeläinen; M Den Hoed; KK Ong; A Grøntved; S Brage; K Jameson; C Cooper; KT Khaw; U Ekelund; NJ Wareham; RJF Loos; RM Freathy; DO Mook-Kanamori; U Sovio; I Prokopenko; NJ Timpson; DJ Berry; NM Warrington; E Widen; JJ Hottenga; M Kaakinen; LA Lange; JP Bradfield; M Kerkhof; JA Marsh; R Mägi; CM Chen; HN Lyon; M Kirin; LS Adair; YS Aulchenko; AJ Bennett; JB Borja; N Bouatia-Naji; P Charoen; LJM Coin; DL Cousminer; EJC De Geus; P Deloukas; P Elliott; DM Evans; P Froguel; B Glaser; CJ Groves; AL Hartikainen; N Hassanali; JN Hirschhorn; A Hofman; JMP Holly; E Hyppönen; S Kanoni; BA Knight; J Laitinen; CM Lindgren; WL McArdle; PF O'Reilly; CE Pennell; DS Postma; A Pouta; A Ramasamy; NW Rayner; SM Ring; F Rivadeneira; BM Shields; DP Strachan; I Surakka; A Taanila; C Tiesler; AG Uitterlinden; CM Van Duijn; AH Wijga; G Willemsen; H Zhang; J Zhao; JF Wilson; EAP Steegers; AT Hattersley; JG Eriksson; L Peltonen; KL Mohlke; SFA Grant; H Hakonarson; GH Koppelman; GV Dedoussis; J Heinrich; MW Gillman; LJ Palmer; TM Frayling; DI Boomsma; GD Smith; C Power; VWV Jaddoe; MR Jarvelin; MI McCarthy

Journal article

Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals

TO Kilpeläinen, M Den Hoed, KK Ong, A Grøntved, S Brage, K Jameson, C Cooper, KT Khaw, U Ekelund, NJ Wareham, RJF Loos, RM Freathy, DO Mook-Kanamori, U Sovio, I Prokopenko, NJ Timpson, DJ Berry, NM Warrington, E Widen, JJ Hottenga Show all

American Journal of Clinical Nutrition | ELSEVIER SCIENCE INC | Published : 2011

DOI: 10.3945/ajcn.110.000828

Abstract

Background: High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background. Objective: The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight. Design: A meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (nmax = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis o..

View full abstract

University of Melbourne Researchers

Lachlan Coin Author

Grants

Awarded by Medical Research Council

Funding Acknowledgements

Supported by program grants from the Medical Research Council UK and Cancer Research UK. The EYHS was supported by grants from the following agencies: The Danish Heart Foundation, The Danish Medical Research Council Health Foundation, The Danish Council for Sports Research, The Foundation in Memory of Asta Florida Bolding Renee Andersen, The Faculty of Health Sciences, University of Southern Denmark, and The Estonian Science Foundation (grants 3277 and 5209). The UK Medical Research Council (grant 74882), the Wellcome Trust (grant 076467), and the University of Bristol provide core support for ALSPAC.