Journal article

Targeting TrkB with a brain-derived neurotrophic factor mimetic promotes myelin repair in the brain

Jessica Fletcher, Rhiannon Wood, Jacqueline Nguyen, Eleanor ML Norman, Christine MK Jun, Alexa Prawdiuk, Melissa Biemond, Huynh TH Nguyen, Susan Northfield, Richard Hughes, David Gonsalvez, Junhua Xiao, Simon Murray

Published : 2018

Abstract

Abstract Methods to promote myelin regeneration in response to central myelin loss are essential to prevent the progression of clinical disability in demyelinating diseases. The neurotrophin brain-derived neurotrophic factor (BDNF) is known to promote myelination during development via oligodendrocyte expressed TrkB receptors. Here, we use a structural mimetic of BDNF to promote myelin regeneration in a preclinical mouse model of central demyelination. We show that selective targeting of TrkB with the BDNF-mimetic enhances remyelination, increasing oligodendrocyte differentiation, the frequency of myelinated axons, and myelin sheath thickness after a demyelinating insult. Treatment with exog..

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