Journal article

Association between excessive premature atrial complexes and cryptogenic stroke: results of a case-control study

Jithin K Sajeev, Anoop N Koshy, Helen Dewey, Jonathan M Kalman, Kevin Rajakariar, Mae C Tan, Maryann Street, Louise Roberts, Jennifer C Cooke, Michael Wong, Tanya Frost, Andrew W Teh

BMJ Open | BMJ PUBLISHING GROUP | Published : 2019


OBJECTIVE: Recent anticoagulation trials in all-comer cryptogenic stroke patients have yielded equivocal results, reinvigorating the focus on identifying reproducible markers of an atrial myopathy. We investigated the role of excessive premature atrial complexes (PACs) in ischaemic stroke, including cryptogenic stroke and its association with vascular risk factors. METHODS AND RESULTS: A case-control study was conducted utilising a multicentre institutional stroke database to compare 461 patients with an ischaemic stroke or transient ischaemic attack (TIA) with a control group consisting of age matched patients without prior history of ischaemic stroke/TIA. All patients underwent 24-hour Hol..

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