Journal article

A Human Depression Circuit Derived From Focal Brain Lesions

Jaya L Padmanabhan, Danielle Cooke, Juho Joutsa, Shan H Siddiqi, Michael Ferguson, R Ryan Darby, Louis Soussand, Andreas Horn, Na Young Kim, Joel L Voss, Andrew M Naidech, Amy Brodtmann, Natalia Egorova, Sophia Gozzi, Thanh G Phan, Maurizio Corbetta, Jordan Grafman, Michael D Fox

Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2019


BACKGROUND: Focal brain lesions can lend insight into the causal neuroanatomical substrate of depression in the human brain. However, studies of lesion location have led to inconsistent results. METHODS: Five independent datasets with different lesion etiologies and measures of postlesion depression were collated (N = 461). Each 3-dimensional lesion location was mapped to a common brain atlas. We used voxel lesion symptom mapping to test for associations between depression and lesion locations. Next, we computed the network of regions functionally connected to each lesion location using a large normative connectome dataset (N = 1000). We used these lesion network maps to test for association..

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Awarded by Academy of Finland

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported in part by funding from the Sidney R. Baer, Jr. Foundation (to JLP, RRD, SHS, and MDF), the Harvard Medical School Department of Psychiatry Dupont-Warren Award (to JLP), the American Psychiatric Association Kempf Award (to JLP), the Alzheimer's Association Clinical Fellowship Program (to RRD), the BrightFocus Foundation Alzheimer's Disease Research Program (to RR), the Vanderbilt Faculty Research Scholars Award (to RRD), the Academy of Finland (Grant No. 295580 [to JJ]), and the National Institutes of Health (Grant Nos. R01MH113929 and K23NS083741 [to MDF]). All funding agencies had no role in the study design, collection, management, analysis, interpretation, preparation, review, interpretation, or submission of this article.