Journal article

APOE epsilon 4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke

Emilio Werden, Mohamed Salah Khlif, Laura J Bird, Toby Cumming, Jennifer Bradshaw, Wasim Khan, Matthew Pase, Carolina Restrepo, Michele Veldsman, Natalia Egorova, Sheila K Patel, Elie Gottlieb, Amy Brodtmann



BACKGROUND: The apolipoprotein E (APOE) gene ɛ4 allele is a risk factor for Alzheimer's disease and cardiovascular disease. However, its relationship with cognition and brain volume after stroke is not clear. OBJECTIVE: We compared cognition and medial temporal lobe volumes in APOEɛ4 carriers and non-carriers in the first year after ischemic stroke. METHODS: We sampled 20 APOEɛ4 carriers and 20 non-carriers from a larger cohort of 135 ischemic stroke participants in the longitudinal CANVAS study. Participants were matched on a range of demographic and stroke characteristics. We used linear mixed-effect models to compare cognitive domain z-scores (attention, processing speed, executive functi..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

We thank our participants who kindly contributed their time to our project. The Florey acknowledges the strong support from the Victorian Government, including funding from the Operational Infrastructure Support Grant. The authors acknowledge the facilities, and the scientific and technical assistance of the National Imaging Faci lity at the Florey Node. The authors also acknowledge the assistance of staff at Austin Health, Eastern Health, and Melbourne Health, who helped to recruit participants into the study.This work was supported by the National Health and Medical Research Council project grant (APP1020526) and Dementia Research Team Grant (APP1094974), the Brain Foundation, Wicking Trust, Collie Trust, and Sidney and Fiona Myer Family Foundation, and Brodtmann's Heart Foundation Future Leader Fellowship.