Journal article

Intrathecal Administration of Losartan Reduces Directly Recorded Cardiac Sympathetic Nerve Activity in Ovine Heart Failure

Simon Leversha, Andrew M Allen, Clive N May, Rohit Ramchandra

Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2019

Abstract

Early and preferential activation of cardiac sympathetic nerve activity (CSNA) is one of the strongest prognostic markers of heart failure (HF) in patients. Our previous studies have implicated central angiotensin mechanisms as playing a critical role in generating this increase in cardiac sympathetic drive. However, it is unclear if inhibition of AT1R (angiotensin type-1 receptors) in different neural groups in the sympathetic pathway to the heart, such as the sympathetic preganglionic neurons in the intermediolateral column of the spinal cord, can reduce cardiac sympathetic drive. We hypothesized that in HF, localized intrathecal administration of the AT1R antagonist losartan, specifically..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Health and Medical Research Council Research Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia Grant 1020783 and by the Victorian Government through the Operational Infrastructure Scheme. R. Ramchandra was the recipient of National Health and Medical Research Council of Australia/National Heart Foundation funded Career Development Fellowship, and C.N. May was supported by a National Health and Medical Research Council Research Fellowship 566819.