Increasing Local Excitability of Brainstem Respiratory Nuclei Reveals a Distributed Network Underlying Respiratory Motor Pattern Formation
Rishi R Dhingra, Werner Furuya, Tara G Bautista, Thomas E Dick, Roberto F Galan, Mathias Dutschmann
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2019
The core circuit of the respiratory central pattern generator (rCPG) is located in the ventrolateral medulla, especially in the pre-Bötzinger complex (pre-BötC) and the neighboring Bötzinger complex (BötC). To test the hypothesis that this core circuit is embedded within an anatomically distributed pattern-generating network, we investigated whether local disinhibition of the nucleus tractus solitarius (NTS), the Kölliker-Fuse nuclei (KFn), or the midbrain periaqueductal gray area (PAG) can similarly affect the respiratory pattern compared to disinhibition of the pre-BötC/BötC core. In arterially-perfused brainstem preparations of rats, we recorded the three-phase respiratory pattern (inspir..View full abstract
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Awarded by ARC
This study was supported by an ARC Future Fellowship to MD and an ARC Discovery grant (DP170104861).