Journal article

A probabilistic-based approach for computational simulation of bone fracture healing

Saeed Miramini, Yi Yang, Lihai Zhang

Computer Methods and Programs in Biomedicine | Elsevier BV | Published : 2019


It is widely known that bone fracture healing is affected by mechanical factors such as fracture geometry, fixation configuration and post-operative weight bearing loading. However, there are several uncertainties associated with the magnitude of the mechanical factors affecting bone healing as it is challenging to adjust and control them in clinical practice. The current bone fracture healing investigations mainly adopt a deterministic approach for identifying the optimal mechanical conditions for a favourable bone healing outcome. However, a probabilistic approach should be used in the analysis to incorporate such uncertainties for prediction of bone healing.