Journal article

Dental pulp stem cells therapy overcome photoreceptor cell death and protects the retina in a rat model of sodium iodate-induced retinal degeneration

Hiba Amer Alsaeedi, Avin Ee-Hwan Koh, Chenshen Lam, Munirah Binti Abd Rashid, Mohd Hairul Nizam Harun, Muhamad Fakhri Bin Mohd Saleh, Seoh Wei Teh, Chi D Luu, Min Hwei Ng, Hazlita Mohd Isa, Sue Ngein Leow, Kong Yong Then, Mae-Lynn Catherine Bastion, Pooi Ling Mok, Bala Sundaram Muthuvenkatachalam, Antony V Samrot, KB Swamy, Jaikumar Nandakumar, Suresh Subbiah Kumar

Journal of Photochemistry and Photobiology B Biology | ELSEVIER SCIENCE SA | Published : 2019

Abstract

Blindness and vision loss contribute to irreversible retinal degeneration, and cellular therapy for retinal cell replacement has the potential to treat individuals who have lost light sensitive photoreceptors in the retina. Retinal cells are well characterized in function, and are a subject of interest in cellular replacement therapy of photoreceptors and the retinal pigment epithelium. However, retinal cell transplantation is limited by various factors, including the choice of potential stem cell source that can show variability in plasticity as well as host tissue integration. Dental pulp is one such source that contains an abundance of stem cells. In this study we used dental pulp-derived..

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University of Melbourne Researchers

Grants

Awarded by Research and Management Centre of Universiti Putra Malaysia through the Putra Graduate Initiative (IPS) grant


Awarded by Research and Management Centre of Universiti Putra Malaysia through Geran Putra Berimpak


Funding Acknowledgements

This research was supported by the Research and Management Centre of Universiti Putra Malaysia through the Putra Graduate Initiative (IPS) grant (Grant No.: 9544300) and Geran Putra Berimpak (Grant No.: 9674600).