Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling
Prajakta Kulkarni-Gosavi, Christian Makhoul, Paul A Gleeson
FEBS LETTERS | WILEY | Published : 2019
In addition to the classical functions of the Golgi in membrane transport and glycosylation, the Golgi apparatus of mammalian cells is now recognised to contribute to the regulation of a range of cellular processes, including mitosis, DNA repair, stress responses, autophagy, apoptosis and inflammation. These processes are often mediated, either directly or indirectly, by membrane scaffold molecules, such as golgins and GRASPs which are located on Golgi membranes. In many cases, these scaffold molecules also link the actin and microtubule cytoskeleton and influence Golgi morphology. An emerging theme is a strong relationship between the morphology of the Golgi and regulation of a variety of s..View full abstract
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Awarded by Australian Research Council
This work was supported by funding from Australian Research Council (DP160102394).