Journal article

Neurocognitive and linguistic correlates of positive and negative formal thought disorder: A meta-analysis

Emre Bora, Berna Yalincetin, Berna Binnur Akdede, Koksal Alptekin

SCHIZOPHRENIA RESEARCH | ELSEVIER | Published : 2019

Abstract

Executive dysfunction and language impairment are the most prominent neuropsychological models of formal thought disorder (FTD) in schizophrenia. However, available studies have provided contradictory findings regarding the accuracy of these models. Furthermore, specific neurocognitive underpinnings of positive FTD (PosFTD) and negative FTD (NegFTD) are not clear. Following the systematic review of schizophrenia studies, a random-effects meta-analysis of the relationship between FTD and neurocognition/language in schizophrenia was conducted in 52 reports including 2805 patients. Neurocognition was significantly associated with both PosFTD (r = -0.21, CI = -0.14 to -0.27) and NegFTD (r = -0.2..

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University of Melbourne Researchers