Early imaging predictors of longer term multiple sclerosis risk and severity in acute optic neuritis

Sanuji Gajamange; Jim Stankovich; Gary Egan; Trevor Kilpatrick; Helmut Butzkueven; Joanne Fielding; Anneke van der Walt; Scott Kolbe

Journal article

Early imaging predictors of longer term multiple sclerosis risk and severity in acute optic neuritis

Sanuji Gajamange, Jim Stankovich, Gary Egan, Trevor Kilpatrick, Helmut Butzkueven, Joanne Fielding, Anneke van der Walt, Scott Kolbe

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL | SAGE PUBLICATIONS INC | Published : 2019

DOI: 10.1177/2055217319863122

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Abstract

Background: Biomarkers are urgently required for predicting the likely progression of multiple sclerosis (MS) at the earliest stages of the disease to aid in personalised therapy. Objective: We aimed to examine early brain volumetric and microstructural changes and retinal nerve fibre layer thinning as predictors of longer term MS severity in patients with clinically isolated syndromes (CIS). Methods: Lesion metrics, brain and regional atrophy, diffusion fractional anisotropy and retinal nerve fibre layer thickness were prospectively assessed in 36 patients with CIS over the first 12 months after presentation and compared with clinical outcomes at longer term follow-up [median (IQR) = 8.5 (7..

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University of Melbourne Researchers

Trevor Kilpatrick Author Florey Department of Neuroscience and Mental Health

Joanne Fielding Author Medicine - Royal Melbourne Hospital

Helmut Butzkueven Author Medicine - Royal Melbourne Hospital

Anneke van der Walt Author Medicine - Royal Melbourne Hospital

Scott Kolbe Author Radiology

Related Projects (2)

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Multiple Sclerosis (MS) is caused by immune attack on the central nervous system (CNS), resulting in loss of the insulating material that su..

UNDERSTANDING THE NEURAL MECHANISMS THAT UNDERLIE RECOVERY AFTER ACUTE OPTIC NEURITIS.

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Grants

Awarded by National MS Society

Awarded by National Health and Medical Research Council of Australia

Awarded by Multiple Sclerosis Research Australia

Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the National MS Society (Grant RG4211A4/2#) and the National Health and Medical Research Council of Australia (Grant APP1009757, APP1054147), Multiple Sclerosis Research Australia (Postgraduate Scholarship #14-088). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.