Journal article

Early imaging predictors of longer term multiple sclerosis risk and severity in acute optic neuritis

Sanuji Gajamange, Jim Stankovich, Gary Egan, Trevor Kilpatrick, Helmut Butzkueven, Joanne Fielding, Anneke van der Walt, Scott Kolbe

MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL | SAGE PUBLICATIONS INC | Published : 2019

Abstract

Background: Biomarkers are urgently required for predicting the likely progression of multiple sclerosis (MS) at the earliest stages of the disease to aid in personalised therapy. Objective: We aimed to examine early brain volumetric and microstructural changes and retinal nerve fibre layer thinning as predictors of longer term MS severity in patients with clinically isolated syndromes (CIS). Methods: Lesion metrics, brain and regional atrophy, diffusion fractional anisotropy and retinal nerve fibre layer thickness were prospectively assessed in 36 patients with CIS over the first 12 months after presentation and compared with clinical outcomes at longer term follow-up [median (IQR) = 8.5 (7..

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Grants

Awarded by National MS Society


Awarded by National Health and Medical Research Council of Australia


Awarded by Multiple Sclerosis Research Australia


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the National MS Society (Grant RG4211A4/2#) and the National Health and Medical Research Council of Australia (Grant APP1009757, APP1054147), Multiple Sclerosis Research Australia (Postgraduate Scholarship #14-088). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.