Journal article

Somatic evolution and global expansion of an ancient transmissible cancer lineage

Adrian Baez-Ortega, Kevin Gori, Andrea Strakova, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Thinlay N Bhutia, Jocelyn L Bisson, Cristobal Briceno, Artemio Castillo Domracheva, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Eric Davis, Karina F de Castro, Andrigo B de Nardi, Anna P de Vos, Laura Delgadillo Keenan, Edward M Donelan, Adela R Espinoza Huerta Show all

SCIENCE | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2019

Abstract

The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displa..

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University of Melbourne Researchers