Journal article

A statistical model for restoration of serum potassium level disturbed by hemolysis

Wei-zheng Zhang, David J Price

Clinica Chimica Acta | ELSEVIER | Published : 2019

Abstract

BACKGROUND: Blood sample hemolysis affects pre-analytical quality and may cause pseudohyperkalemia. We established a statistical model to estimate the corrected potassium (K+) in serum. METHODS: Serum K+ and H index were analyzed, and blood cell index was obtained from the examined Full Blood Examination (FBE) results. A linear-regression model was developed using hemolysis (H) index, K+ and covariates of blood cell index from 139 cell lysates of blood samples. The model was then validated against 26 in vitro physically hemolyzed serum samples. RESULTS: The final model selected H index, hemoglobin concentration (HGB), and hematocrit (HCT) as important predictors in estimating the K+ content...

View full abstract

University of Melbourne Researchers