Journal article
Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in new world primate (Callithrix jacchus) and human pancreatic islets
D Mohanasundaram, C Drogemuller, J Brealey, CF Jessup, C Milner, C Murgia, CJ Lang, A Milton, PD Zalewski, GR Russ, PT Coates
General and Comparative Endocrinology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2011
Abstract
The New world primates (NWP) Callithrix jacchus separated from man approximately 50. million years ago and is a potential alternative small non-human primate model for diabetes research. Ultrastructure, and gene expression of pancreatic islets and the recently described diabetes auto antigenic zinc transporters families in human, NWP and pig pancreas were studied. Morphologically NWP islets were larger than pig islets and similar in size to human islets. NWP islets alpha cells had high dense core surrounded by a limiting membrane, beta cells by the mixed morphology of the granule core, and delta cells by moderate opaque core. Antibody staining for insulin, glucagon, somatostatin and Glucagon..
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Funding Acknowledgements
We thank Juvenile Diabetes Research Foundation International (JDRF) and Australian Islet Consortium for their support in this work. The authors thank the effort of Mrs. Svjetlana Kireta for the helping in sample collection. The authors also thank staff of Renal and Transplant immunology laboratory. We thank the efforts of animal house staff from The Queen Elizabeth Hospital for the maintenance of marmosets.