Journal article

FIRST-TRIMESTER HUMAN TROPHOBLAST IS CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX MRNA( )/ANTIGEN(-)

P GIACOMINI, S TOSI, C MURGIA, F NOBILI, S GAETANI, R GAMBARI, MR NICOTRA, G SIMONI, F MAGGI, PG NATALI

HUMAN IMMUNOLOGY | ELSEVIER SCIENCE INC | Published : 1994

Abstract

Lack of expression of the polymorphic class I and class II MHC antigens in the cytotrophoblast is one of the major factors determining the privileged immunologic status of the placenta. In this report, we show that first-trimester human placental cytotrophoblast cells display moderate to strong expression of class II MHC (HLA-DR alpha and -DR beta) and Ii chain transcripts, apparently in absence of detectable class II antigens and Ii chain. In addition, DR alpha, DR beta, and Ii mRNAs, but not antigens, are consistently upregulated by IFN-gamma. Constitutive expression and upregulation of mRNAs are detectable in trophoblast cells kept in short term as well as prolonged (2-3 weeks) culture. T..

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