Journal article
The influence of opioid dependence on salt consumption and related psychological parameters in mice and humans
CM Smith, JBB Garfield, A Attawar, DI Lubman, AJ Lawrence
Drug and Alcohol Dependence | ELSEVIER IRELAND LTD | Published : 2019
Abstract
Background: The consumption of dietary salt (NaCl) is controlled by neuronal pathways that are modulated by endogenous opioid signalling. The latter is disrupted by chronic use of exogenous opioid receptor agonists, such as morphine. Therefore, opioid dependence may influence salt consumption, which we investigated in two complimentary studies in humans and mice. Methods: Human study: three groups were recruited: i. Individuals who are currently opioid dependent and receiving opioid substitution treatment (OST); ii. Previously opioid dependent individuals, who are currently abstinent, and; iii. Healthy controls with no history of opioid dependence. Participants tasted solutions containing di..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by the National Health and Medical Research Council (NHMRC Project grant 1079891). AJL is an NHMRC Principal Research Fellow (1116930). We also acknowledge the Victorian Government's state infrastructure program.