Journal article

Phenotyping neurons activated in the mouse brain during restoration of salt debt

Craig M Smith, Joshua Cross, Izel M Eraslan, Aparna Attawar, Sarah Ch'ng, Poshmaal Dhar, Rasika Samarasinghe, Laura Gray, Andrew J Lawrence

Journal of Chemical Neuroanatomy | ELSEVIER | Published : 2019


Salt overconsumption contributes to hypertension, which is a major risk factor for stroke, heart and kidney disease. Characterising neuronal pathways that may control salt consumption is therefore important for developing novel approaches for reducing salt overconsumption. Here, we identify neurons within the mouse central amygdala (CeA), lateral parabrachial nucleus (LPBN), intermediate nucleus of the solitary tract (iNTS), and caudal NTS (cNTS) that are activated and display Fos immunoreactivity in mice that have consumed salt in order to restore a salt debt, relative to salt replete and salt depleted controls. Double-label immunohistochemical studies revealed that salt restoring mice had ..

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Awarded by National Health and Medical Research Council Australia

Awarded by NHMRC

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council Australia, Project Grants APP1079891 and APP1141724. AJL is a NHMRC Principal Fellow (1116930). We acknowledge support from the Victorian State Government Operational Infrastructure Scheme.