Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation

Khalid Elsaafien; Willian S Korim; Anthony Setiadi; Clive N May; Song T Yao

Journal article

Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation

Khalid Elsaafien, Willian S Korim, Anthony Setiadi, Clive N May, Song T Yao

FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2019

DOI: 10.3389/fphys.2019.00984

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Abstract

Inflammatory mediators play a critical role in the regulation of sympathetic outflow to cardiovascular organs in hypertension. Emerging evidence highlights the involvement of immune cells in the regulation of blood pressure. However, it is still unclear how these immune cells are activated and recruited to key autonomic brain regions to regulate sympathetic outflow to cardiovascular organs. Chemokines such as C-C motif chemokine ligand 2 (CCL2), and pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), are upregulated both peripherally and centrally in hypertension. More specifically, they are upregulated in key autonomic brain regions that co..

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University of Melbourne Researchers

Willian Korim Author Anatomy and Physiology

Clive May Author Biochemistry and Pharmacology

Song Yao Author Anatomy and Physiology

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Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council Future Fellowship

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (GNT 1079680 to SY; GNT 1128108 to CM and SY), the High Blood Pressure Research Council of Australia, the Rebecca L Cooper Medical Foundation (WK), and the Victorian Government through the Operational Infrastructure Scheme. KE and AS are supported by the Australian Government Research Training Program Scholarships. SY is supported by an Australian Research Council Future Fellowship (FT170100363).