Chemoattraction and Recruitment of Activated Immune Cells, Central Autonomic Control, and Blood Pressure Regulation
Khalid Elsaafien, Willian S Korim, Anthony Setiadi, Clive N May, Song T Yao
FRONTIERS IN PHYSIOLOGY | FRONTIERS MEDIA SA | Published : 2019
Inflammatory mediators play a critical role in the regulation of sympathetic outflow to cardiovascular organs in hypertension. Emerging evidence highlights the involvement of immune cells in the regulation of blood pressure. However, it is still unclear how these immune cells are activated and recruited to key autonomic brain regions to regulate sympathetic outflow to cardiovascular organs. Chemokines such as C-C motif chemokine ligand 2 (CCL2), and pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β), are upregulated both peripherally and centrally in hypertension. More specifically, they are upregulated in key autonomic brain regions that co..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council Future Fellowship
This work was supported by the National Health and Medical Research Council of Australia (GNT 1079680 to SY; GNT 1128108 to CM and SY), the High Blood Pressure Research Council of Australia, the Rebecca L Cooper Medical Foundation (WK), and the Victorian Government through the Operational Infrastructure Scheme. KE and AS are supported by the Australian Government Research Training Program Scholarships. SY is supported by an Australian Research Council Future Fellowship (FT170100363).