Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder A Mendelian Randomization Study

Renato Polimanti; Andrew Ratanatharathorn; Adam X Maihofer; Karmel W Choi; Murray B Stein; Rajendra A Morey; Mark W Logue; Caroline M Nievergelt; Dan J Stein; Karestan C Koenen; Joel Gelernter; Torsten Klengel; Elizabeth G Atkinson; Chia-Yen Chen; Jonathan RI Coleman; Shareefa Dalvie; Laramie E Duncan; Allison C Provost; Katy Torres; Allison E Aiello; Lynn M Almli; Ananda B Amstadter; Soren B Andersen; Ole A Andreassen; Paul A Arbisi; Allison E Ashley-Koch; S Bryn Austin; Esmina Avdibegovic; Dragan Babic; Marie Baekvad-Hansen; Dewleen G Baker; Jean C Beckham; Laura J Bierut; Jonathan I Bisson; Marco P Boks; Elizabeth A Bolger; Anders D Borglum; Bekh Bradley; Megan Brashear; Gerome Breen; Richard A Bryant; Angela C Bustamante; Jonas Bybjerg-Grauholm; Joseph R Calabrese; Jose M Caldas-de-Almeida; Anders M Dale; Mark J Daly; Nikolaos P Daskalakis; Juergen Deckert; Douglas L Delahanty; Michelle F Dennis; Seth G Disner; Katharina Domschke; Alma Dzubur-Kulenovic; Christopher R Erbes; Alexandra Evans; Lindsay A Farrer; Norah C Feeny; Janine D Flory; David Forbes; Carol E Franz; Sandro Galea; Melanie E Garrett; Bizu Gelaye; Joel Gelernter; Elbert Geuze; Charles Gillespie; Aferdita Goci Uka; Scott D Gordon; Guia Guffanti; Rasha Hammamieh; Supriya Harnal; Michael A Hauser; Andrew C Heath; Sian MJ Hemmings; David Michael Hougaard; Miro Jakovljevic; Marti Jett; Eric Otto Johnson; Ian Jones; Tanja Jovanovic; Xue-Jun Qin; Angela G Junglen; Karen-Inge Karstoft; Milissa L Kaufman; Ronald C Kessler; Alaptagin Khan; Nathan A Kimbrel; Anthony P King; Nastassja Koen; Henry R Kranzler; William S Kremen; Bruce R Lawford; Lauren AM Lebois; Catrin E Lewis; Sarah D Linnstaedt; Adriana Lori; Bozo Lugonja; Jurjen J Luykx; Michael J Lyons; Jessica Maples-Keller; Charles Marmar; Alicia R Martin; Nicholas G Martin; Douglas Maurer; Matig R Mavissakalian; Alexander McFarlane; Regina E McGlinchey; Katie A McLaughlin; Samuel A McLean; Sarah McLeay; Divya Mehta; William P Milberg; Mark W Miller; Charles Phillip Morris; Ole Mors; Preben B Mortensen; Benjamin M Neale; Elliot C Nelson; Merete Nordentoft; Sonya B Norman; Meaghan O'Donnell; Holly K Orcutt; Matthew S Panizzon; Edward S Peters; Alan L Peterson; Matthew Peverill; Robert H Pietrzak; Melissa A Polusny; John P Rice; Stephan Ripke; Victoria B Risbrough; Andrea L Roberts; Alex O Rothbaum; Barbara O Rothbaum; Peter Roy-Byrne; Ken Ruggiero; Ariane Rung; Bart PF Rutten; Nancy L Saccone; Sixto E Sanchez; Dick Schijven; Soraya Seedat; Antonia V Seligowski; Julia S Seng; Christina M Sheerin; Derrick Silove; Alicia K Smith; Jordan W Smoller; Nadia Solovieff; Scott R Sponheim; Dan J Stein; Jennifer A Sumner; Martin H Teicher; Wesley K Thompson; Edward Trapido; Monica Uddin; Robert J Ursano; Leigh Luella van den Heuvel; Miranda van Hooff; Eric Vermetten; Christiaan H Vinkers; Joanne Voisey; Yunpeng Wang; Zhewu Wang; Thomas Werge; Michelle A Williams; Douglas E Williamson; Sherry Winternitz; Christiane Wolf; Erika J Wolf; Jonathan D Wolff; Rachel Yehuda; Keith A Young; Ross McD Young; Hongyu Zhao; Lori A Zoellner; Israel Liberzon; Kerry J Ressler; Magali Haas; Karestan C Koenen

Journal article

Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder A Mendelian Randomization Study

Renato Polimanti, Andrew Ratanatharathorn, Adam X Maihofer, Karmel W Choi, Murray B Stein, Rajendra A Morey, Mark W Logue, Caroline M Nievergelt, Dan J Stein, Karestan C Koenen, Joel Gelernter, Torsten Klengel, Elizabeth G Atkinson, Chia-Yen Chen, Jonathan RI Coleman, Shareefa Dalvie, Laramie E Duncan, Allison C Provost, Katy Torres, Allison E Aiello Show all

JAMA NETWORK OPEN | AMER MEDICAL ASSOC | Published : 2019

DOI: 10.1001/jamanetworkopen.2019.3447

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Abstract

IMPORTANCE: There is a well-established negative association of educational attainment (EA) and other traits related to cognitive ability with posttraumatic stress disorder (PTSD), but the underlying mechanisms are poorly understood. OBJECTIVES: To investigate the association of PTSD with traits related to EA. DESIGN, SETTING, AND PARTICIPANTS: Genetic correlation, polygenic risk scoring, and mendelian randomization (MR) were conducted including 23 185 individuals with PTSD and 151 309 control participants from the Psychiatric Genomics Consortium for PTSD and up to 1 131 881 individuals assessed for EA and related traits from UK Biobank, 23andMe, and the Social Science Genetic Association Co..

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University of Melbourne Researchers

David Forbes Author

Meaghan O'Donnell Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This study was supported by grants R01 MH106595 and U01 MH109532 from the National Institutes of Health and by the Veterans Affairs National Center for Posttraumatic Stress Disorder Research.