Journal article

Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder A Mendelian Randomization Study

Renato Polimanti, Andrew Ratanatharathorn, Adam X Maihofer, Karmel W Choi, Murray B Stein, Rajendra A Morey, Mark W Logue, Caroline M Nievergelt, Dan J Stein, Karestan C Koenen, Joel Gelernter, Caroline M Nievergelt, Adam X Maihofer, Torsten Klengel, Elizabeth G Atkinson, Chia-Yen Chen, Jonathan RI Coleman, Shareefa Dalvie, Laramie E Duncan, Mark W Logue Show all

JAMA NETWORK OPEN | AMER MEDICAL ASSOC | Published : 2019

Abstract

Importance: There is a well-established negative association of educational attainment (EA) and other traits related to cognitive ability with posttraumatic stress disorder (PTSD), but the underlying mechanisms are poorly understood. Objectives: To investigate the association of PTSD with traits related to EA. Design, Setting, and Participants: Genetic correlation, polygenic risk scoring, and mendelian randomization (MR) were conducted including 23 185 individuals with PTSD and 151 309 control participants from the Psychiatric Genomics Consortium for PTSD and up to 1 131 881 individuals assessed for EA and related traits from UK Biobank, 23andMe, and the Social Science Genetic Association Co..

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