Journal article
Association of Economic Status and Educational Attainment With Posttraumatic Stress Disorder A Mendelian Randomization Study
Renato Polimanti, Andrew Ratanatharathorn, Adam X Maihofer, Karmel W Choi, Murray B Stein, Rajendra A Morey, Mark W Logue, Caroline M Nievergelt, Dan J Stein, Karestan C Koenen, Joel Gelernter, Caroline M Nievergelt, Adam X Maihofer, Torsten Klengel, Elizabeth G Atkinson, Chia-Yen Chen, Jonathan RI Coleman, Shareefa Dalvie, Laramie E Duncan, Mark W Logue Show all
JAMA NETWORK OPEN | AMER MEDICAL ASSOC | Published : 2019
Abstract
Importance: There is a well-established negative association of educational attainment (EA) and other traits related to cognitive ability with posttraumatic stress disorder (PTSD), but the underlying mechanisms are poorly understood. Objectives: To investigate the association of PTSD with traits related to EA. Design, Setting, and Participants: Genetic correlation, polygenic risk scoring, and mendelian randomization (MR) were conducted including 23 185 individuals with PTSD and 151 309 control participants from the Psychiatric Genomics Consortium for PTSD and up to 1 131 881 individuals assessed for EA and related traits from UK Biobank, 23andMe, and the Social Science Genetic Association Co..
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Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH
Funding Acknowledgements
This study was supported by grants R01 MH106595 and U01 MH109532 from the National Institutes of Health and by the Veterans Affairs National Center for Posttraumatic Stress Disorder Research.