Journal article

In-utero Exposure to Maternal Stressful Life Events and Risk of Cryptorchidism: The Raine Study

Elvira Brauner, Martha Hickey, Ase Marie Hansen, Dorota A Doherty, David J Handelsman, Anders Juul, Roger Hart



Cryptorchidism, registered at birth or later, is the most common birth defect in males in western countries, estimated to affect around 2-3% of newborn boys, declining to around 2% at 3 months. We have previously described a potential association between stressful life events (SLEs) in pregnancy and reduced semen quality and testosterone levels in adult offspring. Both outcomes are believed to share a common etiology with cryptorchidism thus increased risk of cryptorchidism in boys exposed to prenatal SLEs may be plausible. The risk of cryptorchidism associated with prenatal SLE amongst 1,273 male Generation 2 offspring was estimated using the Western Australian Pregnancy (Raine) Study. SLEs..

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Awarded by Australian NHMRC

Funding Acknowledgements

The core management of the Raine Study was funded by University of Western Australia, Curtin University, Telethon Kids Institute, Women and Infants Research Foundation, Edith Cowan University, Murdoch University, The University of Notre Dame Australia, Raine Medical Research Foundation for providing funding to core management of the Raine Study, and by Australian NHMRC Grant Number 634457. EB salary was supported by Laege Sofus Carl Emil Friis og Hustru Olga Doris Friis Foundation, in Denmark.