Journal article

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

Henrike Johanna Gothe, Britta Annika Maria Bouwman, Eduardo Gade Gusmao, Rossana Piccinno, Giuseppe Petrosino, Sergi Sayols, Oliver Drechsel, Vera Minneker, Natasa Josipovic, Athanasia Mizi, Christian Friberg Nielsen, Eva-Maria Wagner, Shunichi Takeda, Hiroyuki Sasanuma, Damien Francis Hudson, Thomas Kindler, Laura Baranello, Argyris Papantonis, Nicola Crosetto, Vassilis Roukos

Molecular Cell | CELL PRESS | Published : 2019


Awarded by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)

Awarded by Swedish Research Council

Awarded by Swedish Cancer Research Foundation

Awarded by German Ministry for Research (DFG)

Awarded by DFG Major Research Instrumentation Programme

Awarded by Microscopy and Histology Core Facility

Awarded by Genomics Core Facility

Funding Acknowledgements

We are grateful to Tom Misteli and Gianluca Pegoraro for critical reading of the manuscript. We thank Reza Mirzazadeh and Silvano Garnerone for support with BLISS experiments and processing and Prof. Andy Porter and Leszek Wojnowski for sharing reagents. Work in the V.R. lab is funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation; project number 393547839 - SFB 1361, subproject 13) and a Naturwissenschaftlich-medizinisches Forschungszentrum (NMFZ) grant. Work in the N.C. lab is supported by the Swedish Research Council (521-2014-2866), the Swedish Cancer Research Foundation (CAN 2015/585), the Ragnar Soderberg Foundation, and the Strategic Research Programme in Cancer (StratCan) at Karolinska Institutet. Work in the A.P. lab is supported by CMMC core funding and the German Ministry for Research (DFG; grant PA2456/4-1). Work in H.S. and S.T. labs is supported by JSPS Core-to-Core Program. B.B. was supported by a Rubicon postdoctoral scholarship from NOW in the Netherlands. The Opera Phenix high-content screening system is supported by the "DFG Major Research Instrumentation Programme" (INST 247/845-1 FUGG). Support by the Microscopy and Histology Core Facility and the Genomics Core Facility and the use of its NextSeq500 (INST 247/870-1 FUGG) is also gratefully acknowledged.