Journal article

Impact of High-Dose Caffeine on the Preterm Ovine Cerebrum and Cerebellum

Anzari Atik, Robert De Matteo, Meghan Boomgardt, Sandra Rees, Richard Harding, Jeanie Cheong, Shreya Rana, Kelly Crossley, Mary Tolcos



Caffeine is one of the few treatments available for infants with apnea of prematurity. As the recommended dosing regimen is not always sufficient to prevent apnea, higher doses may be prescribed. However, little is currently known about the impact of high-dose caffeine on the developing brain; thus, our aim was to investigate the consequences of a high-dose regimen on the immature ovine brain. High-dose caffeine (25 mg/kg caffeine base loading dose; 20 mg/kg daily maintenance dose; n = 9) or saline (n = 8) was administered to pregnant sheep from 105 to 118 days of gestation (DG; term = 147 days); this is broadly equivalent to 28-33 weeks of human gestation. At 119DG, the cerebral cortex, str..

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Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

Funding for this study was provided by the National Health and Medical Research Council of Australia (ID 628312) to MT, JC, RDM, SaR, and RH, Early Career Fellowship ID 1053787 to JC, and the Victorian Government's Operational Infrastructure Support Program (Government of Victoria).