Journal article

The current status of blood epigenetic biomarkers for dementia

Peter D Fransquet, Joanne Ryan

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES | TAYLOR & FRANCIS LTD | Published : 2019

Abstract

Dementia is an overarching term which describes a group of symptoms that result in long-term decline in cognitive functioning that is significant enough to affect daily function. It is caused by a number of different diseases, the most common of which is Alzheimer's disease. Currently, there are no definitive biomarkers for preclinical or diagnostic use, or which differentiate between underlying disease types. The purpose of this review is to highlight several important areas of research on blood-based biomarkers of dementia, with a specific focus on epigenetic biomarkers. A systematic search of the literature identified 77 studies that compared blood DNA methylation between individuals with..

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