Using transcription factors for direct reprogramming of neurons in vitro
Layal El Wazan, Daniel Urrutia-Cabrera, Raymond Ching-Bong Wong
WORLD JOURNAL OF STEM CELLS | BAISHIDENG PUBLISHING GROUP INC | Published : 2019
Cell therapy offers great promises in replacing the neurons lost due to neurodegenerative diseases or injuries. However, a key challenge is the cellular source for transplantation which is often limited by donor availability. Direct reprogramming provides an exciting avenue to generate specialized neuron subtypes in vitro, which have the potential to be used for autologous transplantation, as well as generation of patient-specific disease models in the lab for drug discovery and testing gene therapy. Here we present a detailed review on transcription factors that promote direct reprogramming of specific neuronal subtypes with particular focus on glutamatergic, GABAergic, dopaminergic, sensor..View full abstract
Supported by funding from the Ophthalmic Research Institute of Australia, the University of Melbourne De Brettville Trust, the Kel and Rosie Day Foundation and the Centre for Eye Research Australia. The Centre for Eye Research Australia receives operational infrastructure support from the Victorian Government.