Journal article

Engineering Biocoatings To Prolong Drug Release from Supraparticles

Yutian Ma, Christina Cortez-Jugo, Jianhua Li, Zhixing Lin, Rachael T Richardson, Yiyuan Han, Jiajing Zhou, Mattias Bjornmalm, Orlagh M Feeney, Qi-Zhi Zhong, Christopher JH Porter, Andrew K Wise, Frank Caruso

Biomacromolecules | American Chemical Society | Published : 2019

Abstract

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of interest for long-term, sustained drug release in biomedical applications. However, a key challenge to achieving temporal control of drug release from SPs is the occurrence of an initial rapid release of the loaded drug (i.e., “burst” release) that limits sustained release and potentially causes burst release-associated drug toxicity. Herein, a biocoating strategy is presented for silica-SPs (Si-SPs) to reduce the extent of burst release of the loaded model protein lysozyme. Specifically, Si-SPs were coated with a fibrin film, formed by enzymatic conversion of fibrinoge..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by US Department of Defense


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by European Union


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036), the Australian National Health and Medical Research Council (NHMRC) Project grants GNT1064375 and GNT1142910, the US Department of Defense (W81XWH1810276), and the Robert Bulley Foundation. F.C. acknowledges the award of an NHMRC Senior Principal Research Fellowship (GNT1135806). The Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. M.B. acknowledges support from Horizon 2020 (European Union) through a Marie Sklodowska-Curie Individual Fellowship (grant agreement no. 745676). We also thank Dr. Yi Ju and Yijiao Qu for helpful discussions.