Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection.
Benjamin M Tang, Maryam Shojaei, Sally Teoh, Adrienne Meyers, John Ho, T Blake Ball, Yoav Keynan, Amarnath Pisipati, Aseem Kumar, Damon P Eisen, Kevin Lai, Mark Gillett, Rahul Santram, Robert Geffers, Jens Schreiber, Khyobeni Mozhui, Stephen Huang, Grant P Parnell, Marek Nalos, Monika Holubova Show all
Nat Commun | Published : 2019
Severe influenza infection has no effective treatment available. One of the key barriers to developing host-directed therapy is a lack of reliable prognostic factors needed to guide such therapy. Here, we use a network analysis approach to identify host factors associated with severe influenza and fatal outcome. In influenza patients with moderate-to-severe diseases, we uncover a complex landscape of immunological pathways, with the main changes occurring in pathways related to circulating neutrophils. Patients with severe disease display excessive neutrophil extracellular traps formation, neutrophil-inflammation and delayed apoptosis, all of which have been associated with fatal outcome in ..View full abstract