Journal article

Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability

Philipp Diehl, Frederik Nienaber, Maria TK Zaldivia, Johannes Stamm, Patrick M Siegel, Natalie A Mellett, Marius Wessinger, Xiaowei Wang, James D McFadyen, Nicole Bassler, Gerhard Puetz, Nay M Htun, David Braig, Jonathon Habersberger, Thomas Helbing, Steffen U Eisenhardt, Maria Fuller, Christoph Bode, Peter J Meikle, Yung Chih Chen Show all



BACKGROUND:  Microvesicles (MVs) are small cell-derived vesicles, which are mainly released by activated cells. They are part of a communication network delivering biomolecules, for example, inflammatory molecules, via the blood circulation to remote cells in the body. Platelet-derived MVs are known to induce vascular inflammation. Research on the mediators and mechanisms of their inflammatory effects has attracted major interest. We hypothesize that specific lipids are the mediators of vascular inflammation caused by platelet-derived MVs. METHODS AND RESULTS:  Liquid chromatography electrospray ionization-tandem mass spectrometry was used for lipid profiling of platelet-derived MVs. Lysopho..

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Awarded by German Research Foundation (DFG)

Funding Acknowledgements

P.D. was funded by scholarships from the German Research Foundation (DFG, DI 1623/1-1) and Monash University in Melbourne (Australia), J.D.M. and N.M.H. were funded by Royal Australasian College of Physicians research establishment fellowships, S.U.E. was funded by a professorial Heisenberg Fellowship from the German Research Foundation (DFG) and X.W. and Y.C.C. were funded by a fellowship from the Heart Foundation of Australia. P.J.M. and K.P. were funded by fellowships from the National Health and Medical Research Council (NHMRC) of Australia. The project was also supported in part by the Victorian Government's OIS Program.