Journal article

Plasma levels of the soluble form of the Fc gamma RIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Jianlin Qiao, Eimear Dunne, Bruce Wines, Dermot Kenny, Geraldine M McCarthy, P Mark Hogarth, Kailin Xu, Robert K Andrews, Elizabeth E Gardiner

PLATELETS | TAYLOR & FRANCIS INC | Published : 2019

Abstract

Soluble forms of the low-affinity immunoglobulin receptor FcγRIIa (sFcγRIIa) lacking the cytoplasmic tail have been reported in plasma however the mechanism and functional consequences are unknown. This study aimed to evaluate mechanisms of FcγRIIa release compared to GPVI release from platelets, and examine whether genetic polymorphisms at positions 27 and 131 within FcγRIIa correlate with platelet FcγRIIa stability and function. Enzyme-linked immunosorbent assays (ELISAs) were used to measure plasma sFcγRIIa and sGPVI levels. FcγRIIa genotype at positions 27 and 131 was evaluated. sFcγRIIa levels were not significantly different between non-131HH and 131HH but were significantly lower in 2..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by Natural Science Foundation of Jiangsu Province


Awarded by Six Talent Peaks Project of Jiangsu Province


Awarded by 333 projects of Jiangsu Province


Funding Acknowledgements

This research was supported by the National Health and Medical Research Council of Australia, National Natural Science Foundation of China [grant no. 81400082]; the Natural Science Foundation of Jiangsu Province [BK20140219]; the funding for the Distinguished Professorship Program of Jiangsu Province, the Six Talent Peaks Project of Jiangsu Province (WSN-133), the Shuangchuang Project of Jiangsu Province, the 333 projects of Jiangsu Province [BRA2017542]; the Science and Technology Foundation for the Selected Overseas Chinese Scholars, State Ministry of Human Resources and Social Security.