Journal article

The biology and functional importance of MAIT cells

Dale Godfrey, Hui-Fern Koay, James McCluskey, Nicholas A Gherardin

NATURE IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2019

Abstract

In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative antigens presented by the major histocompatibility complex (MHC) class I-like protein MR1. MAIT cells use a limited T cell antigen receptor (TCR) repertoire with public antigen specificities that are conserved across species. They can be activated by TCR-dependent and TCR-independent mechanisms and exhibit rapid, innate-like effector responses. He..

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Australian Research Council (ARC)


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC ECF Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (NHMRC; 1113293 and 1140126); the Australian Research Council (ARC; CE140100011) and the Cancer Council of Victoria (#). DIG is supported by NHMRC Senior Principal Research Fellowship (1117766). H-F.K is supported by an NHMRC ECF Fellowship (1160333).