Journal article

Vancomycin is commonly under-dosed in critically ill children and neonates

Natasha Sosnin, Nigel Curtis, Noel Cranswick, Roberto Chiletti, Amanda Gwee

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | WILEY | Published : 2019

Abstract

AIMS: Vancomycin is frequently used in critically ill children in whom the drug pharmacokinetics are significantly altered as a result of changes in renal clearance and volume of distribution. Therapeutic drug monitoring (TDM) is recommended to achieve vancomycin trough concentrations between 10 and 20 mg/L. In this study we reviewed vancomycin dosing, TDM and treatment outcomes in paediatric and neonatal intensive care unit patients. METHODS: We reviewed the medical records of all patients receiving intravenous vancomycin in a tertiary paediatric and neonatal intensive care unit over a 10-month period. Demographic, vancomycin dosing, TDM and drug-related adverse effects data were collected...

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